Aciclovir & Hydrocortisone: Uses, Dosage, Side Effects

Generic Name
Aciclovir & Hydrocortisone
Therapeutic Class: (Topical viral infection products) Hydrocortisone & Combined preparations

Acyclovir & Hydrocortisone Cream is indicated for the first treatment of recurrent oral herpes (cold sores) to scale back the likelihood of ulcerative cold sores and to shorten the lesion healing time in adults and youngsters (6 years aged and older).

Acyclovir may be a synthetic purine nucleoside analog with inhibitory activity against Herpes simplex viruses type 1 (HSV-1) and sort 2 (HSV-2) in cell culture and in vivo. The inhibitory activity of Acyclovir is very selective thanks to its affinity for the enzyme thymidine kinase (TK) encoded by HSV. This viral enzyme converts Acyclovir into Acyclovir monophosphate, a nucleotide analog. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a variety of cellular enzymes. In cell culture, Acyclovir triphosphate stops the replication of herpes viral DNA. This inhibition is accomplished in 3 ways:

  • Competitive inhibition of viral DNA polymerase
  • Incorporation into and termination of the growing viral DNA chain
  • Inactivation of the viral DNA polymerase

Hydrocortisone is that the main glucocorticoid secreted by the cortex. it's used topically for its anti-inflammatory effects which suppress the clinical manifestations of the disease during a wide selection of disorders where inflammation may be a prominent feature.

Dosage & Administration:
The cream should be topically applied 5 times per day for five days. Therapy should be initiated as early as possible after the primary signs and symptoms.

No information is available.

There is no known contraindication.

Side Effects:
The following most common adverse reactions (<1%) were local skin reactions like drying or flaking of the skin; burning or tingling, erythema; pigmentation changes, application site reactions including signs and symptoms of inflammation.

Pregnancy & Lactation:
Pregnancy Category B. There are not any adequate and well-controlled studies of systemic acyclovir in pregnant women. No studies are performed on pregnant women. Systemic exposure of Acyclovir and Hydrocortisone following topical administration of this cream is minimal. it's not known whether topically applied Acyclovir or Hydrocortisone is excreted in breast milk. Because many drugs are excreted in human milk, caution should be exercised when administered to a nursing woman.

Precautions & Warnings:
Acyclovir and Hydrocortisone shouldn't be utilized in the attention, inside the mouth or nose, or on the genitals. Patients should seek medical advice when a chilly sore fails to heal within 2 weeks.

Keep below 30°C temperature, far away from light & moisture. exclude the reach of youngsters.


Post a Comment