Adapalene: Uses, Dosage, Side Effects

Generic Name
Therapeutic Class: Topical retinoid and related preparations

Adapalene acts on retinoid receptors that are commonly found within the skin of the face, back, and chest. Biochemical and pharmacological studies have demonstrated that Adapalene may be a modulator of cellular differentiation, keratinization, and inflammatory processes, all of that represent important features within the pathology of acne. Adapalene binds with specific retinoic acid nuclear receptors that normalize the differentiation of follicular epithelial cells leading to decreased microcomedone formation. The absorption of Adapalene through human skin is low.

Adapalene cream or gel is indicated for the topical treatment of acne.

Dosage & Administration:
  • Adapalene 0.1% cream: It should be applied to the affected areas of skin, once daily at night-time.
  • Adapalene 0.3% gel: It should be applied to the whole face and the other affected areas of the skin, once daily within the evening.
  • A thin film of gel or cream should be applied to the skin areas where lesions present, using enough to hide the whole affected areas lightly
Concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps, and cosmetics that have a robust drying effect, products with high concentrations of alcohol, astringents, spices, or lime) should be approached with caution.
Exercise particular caution in using preparations containing sulfur, resorcinol, or 2-hydroxybenzoic acid together with Adapalene.

If any of those preparations are used, it's advisable to not start therapy with Adapalene until the consequences of such preparations in the skin have subsided. If the combined use of both medications is vital, it's better to use it at two different times.

Adapalene shouldn't be administered to individuals who are hypersensitive to Adapalene or any of its components.

Side Effects:
Erythema, scaling, dryness, pruritus, burning sensation, skin irritation, stinging sunburn, acne flares, etc. are commonly seen during the primary month of therapy but usually lessen with continued use of the medication.

Pregnancy & Lactation:
Use Adapalene during pregnancy as long as the potential benefit justifies the potential risk to the fetus. it's not known whether this drug is excreted in breast milk. Exercise caution when administering Adapalene to a nursing mother.

Precautions & Warnings:
Adapalene shouldn't be applied to cuts, abrasions, eczematous or sunburned skin.

Store during a cool (below 25°C) and dry place shielded from light and moisture. exclude the reach of children. Keep the tube tightly closed after use.

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