Antacids (Aluminium Hydroxide + Magnesium Hydroxide + Simethicone)

Generic Name
Antacids(Aluminium Hydroxide + Magnesium Hydroxide + Simethicone)

Pharmacology :
This is the mixture of non-systemic acid-neutralizing substances and antiflatulent. This preparation offers reliability also as long action. aluminum hydroxide and milk of magnesia induce the relief of ulcer by neutralizing gastric acid secreted from parietal cells of the stomach. The clinical use of simethicone is predicated on its antifoam properties. Simethicone spreads on the surface of aqueous liquids, forming a movie of low physical phenomenon and causing the collapse of froth bubbles. Simethicone repeatedly allows mucous surrounded gas bubbles within the alimentary canal to coalesce and be expelled.
This is utilized in the treatment of flatulence and meteorism for the elimination of gas, air, or foam from the alimentary canal before radiography and for the relief of abdominal distension and dyspepsia.
Simethicone is physiologically inert; it doesn't appear to be absorbed from the alimentary canal to interfere with gastric secretion or absorption of nutrients. Following oral administration, the drug is excreted unchanged within the feces.

Indications :
This is indicated for symptomatic relief of hyperacidity related to peptic ulceration, gastritis, peptic oesophagitis, gastric hyperacidity, heartburn, sour stomach, or hiatal hernia. it's effective within the prevention of stress ulceration and GI bleeding. It acts as an antiflatulent to alleviate the symptoms of gas including post-operative gas pain. This rapidly relieves acid pain, disperses gastric foam, and facilitates the eructation of gas and air.

Dosage & Administration :
Tablet: 1-2 tablets 1-3 hours after a meal and at bedtime or as directed by the physician.
Suspension: 1-2 teaspoonful 1-3 hours after a meal and at bedtime or as directed by the physician.

Interaction :
All antacids may increase or decrease the speed and/or extent of absorption of concomitantly administered oral drugs. Antacids decrease the bioavailability of theophylline, tetracycline, quinolone antibiotics, isoniazid, ketoconazole, ethambutol, some antimuscarinic drugs, benzodiazepines, phenothiazines, ranitidine, indomethacin, nitrofurantoin, fluoride, phosphate, propranolol, atenolol, digoxins, vitamins, etc. Antacids increase the bioavailability of some drugs; e.g. sulphonamides, levodopa, Depokene, aspirin, etc.

Contraindications :
This should not be administered in patients with kidney failure or hypophosphatemia or in those that are severely debilitated. it's also contraindicated in alkalosis and hypermagnesaemia, where abdominal distention could also be thanks to partial or complete ileus.

Side Effects :
Gastrointestinal side effects are uncommon. Occasionally, if an excessive amount is consumed, diarrhea, constipation, or regurgitation may occur.

Pregnancy & Lactation :
It is advised to avoid antacid preparations within the trimester of pregnancy.

Precautions & Warnings :
This should be used with caution in patients with renal disorders.

Storage :
Keep below 30°C temperature, faraway from light & moisture. exclude the reach of children.

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